Bilbao striker Fernando Llorente has scored six goals against Valencia and is hoping to add to that tally when they clash again on Sunday.
Atletico Madrid striker Radamel Falcao did not train on Friday due to neck problem, but he is likely to recover in time to face Real Mallorca.
Barcelona are reported keeping an eye on teenager Nicola Leali, who has been labelled as the 'new Buffon' by Brescia president Luigi Corioni.
Espanyol will be hoping to register their second away victory when they take on Racing, who are keen to avoid their second straight defeat.
Pedro Leon and Miguel Angel Moya have shaken off their injuries and in Getafe's squad to face Sociedad, although both are unlikely to start.
Granada are hoping to register their first away win when they take on Sporting Gijon, who are determined to avoid their third straight defeat.
Coach Juan Ignacio said Levante will approach the match against Villarreal with the utmost respect, but it will not stop them from competing.
Malaga are pondering a January move for Porto striker Hulk and could submit a EUR40 million offer when the transfer market reopens in January.
Osasuna striker Kike Sola has defended Jose Luis Mendilibar after his controversial statement and said he is a coach who knows what to do.
Racing are keen to avoid their second straight defeat when they take on Espanyol, who will be hoping to register their second away victory.
Rayo Vallecano goalkeeper Dani Gimenez believes the match against Betis will be key and that his side will retain their attacking approach.
Real Betis coach Pepe Mel has played down their three straight defeats and reminded his team that they are currently occupying seventh place.
Real Madrid manager Jose Mourinho insists Cristiano Ronaldo is not a selfish player as his 5 assists in the last 3 games proved that point.
Mallorca supporters declared that they are tired of interferences, threats and the bad treatment by those who come to club only to make money.
Sociedad coach Philippe Montanier is not worried about their losing streak and is convinced that with focus, they can get out of the slump.
Zaragoza goalkeeper Roberto Jimenez is aware how important the Osasuna clash is, but claims he thrives playing in a pressure cooker situation.
Sevilla coach Marcelino Garcia Toral will not admit defeat before the battle, but admits the Barcelona clash will be different from the rest.
Sporting Gijon are determined to avoid their third straight defeat when they take on Granada, who are hoping to register their first away win.
Vicente Guaita said the Valencia team are angry after the defeat to Leverkusen and insisted they are not thinking about the Europa League.
Villarreal striker Giuseppe Rossi will not be leaving the Spanish side for Serie A, insists the club's vice-president Jose Manuel Llaneza.