Athletic Bilbao are confident of picking up points for the fifth straight game when they face Atletico, who have yet to win when playing away.
Atletico Madrid playmaker Diego has stressed that coach Gregorio Manzano should not be solely responsible for the club's poor run of form.
Xavi Hernandez scored his fourth La Liga goal of the season as Barcelona registered their second away win following the match against Granada.
Espanyol striker Alvaro Vazquez has insisted that he is not worried about his goal drought as long as his side are producing good results.
Getafe are determined to register their first win in four games when they take on Osasuna, who are looking to avoid their third away defeat.
Xavi Hernandez scored his fourth La Liga goal of the season to condemned Granada to their second home defeat following the visit of Barcelona.
Levante midfielder Valdo declared that his team will do all they can to defend their position at the top of the table for as long as possible.
Malaga coach Manuel Pellegrini will have Willy Caballero back from his ban, while Duda and Juanmi also returned after shaking off injuries.
Osasuna coach Jose Luis Mendilibar has stressed it is equally important for his side to change the image that they can only play well at home.
Jairo Samperio scored his first La Liga goal of the season as Racing registered their second away draw following the match against Sevilla.
Rayo are hoping to pick up points for the third tim in five games when they take on Malaga, who are looking for their second away victory.
Real Betis midfielder Jose Canas has stressed that his team are determined to win their next two games against Espanyol and Racing Santander.
Assistant coach Aitor Karanka is expecting Villarreal to create a lot of problems for Real Madrid, despite their lowly position in the league.
Mallorca are looking for their third home win when they take on Sporting Gijon, who are hoping to pick up points for the second straight game.
Real Sociedad will be hoping to pick up points for the second time in five games when they face Levante, who have won all their home games.
Real Zaragoza are hoping to avoid their second consecutive defeat when they take on Valencia, who are looking for their second away victory.
Manu Del Moral scored his third La Liga goal of the season as Sevilla registered their first home draw following the match against Racing.
Sporting Gijon are hoping to pick up points for the second straight game when they face Mallorca, who are looking for their third home win.
Coach Unai Emery is determined to improve Valencia's image at La Romareda after their poor displays against the host in the last two seasons.
Villarreal boss Juan Carlos Garrido is hoping the extra motivation for the big clash against Real Madrid will help his side get back on track.