Bilbao striker Fernando Llorente has been given the green light to return to action after missing the last two fixtures with a hip injury.
Atletico Madrid coach Diego Simeone said his team must show determination against Real Zaragoza, who will prove to be a difficult opponents.
Lionel Messi scored his 35th La Liga goal of the season as Barcelona registered their 13th home victory following the match against Mallorca.
Espanyol boss Mauricio Pochettino will be paying special attention to Malaga's set-pieces and believes ball possession will be key to the game.
Granada midfielder Fran Rico has warned his side to be wary of Sevilla, who will enter the match with more confidence after the win at Racing.
Levante coach Juan Ignacio Martinez has included Juanlu Gomez in his squad for the first time since the midfielder was injured 3 months ago.
Malaga midfielder Jeremy Toulalan will undergo surgery on his broken metatarsal on Tuesday and is likely to be out for the rest of the season.
Boss Jose Luis Mendilibar would love to see a daring Osasuna away from home, but believes he cannot complain about their conservative approach.
Racing coach Alvaro Cervera has blamed himself for their 3 straight defeats, claiming that he has failed to explain his idea to the players.
Rayo Vallecano coach Jose Ramon Sandoval expects to meet a different Villarreal side following the arrival of manager Miguel Angel Lotina.
Real Betis coach Pepe Mel will have to take on Racing Santander without the services of Fabrizio, Iriney and Pereira due to various injuries.
Cristiano Ronaldo scored his 35th La Liga goal of the term as Real Madrid registered their 13th home win following the match against Sociedad.
Lionel Messi scored his 35th La Liga goal of the season to condemned Mallorca to their 6th away defeat following the match against Barcelona.
Cristiano Ronaldo scored his 35th La Liga goal to condemned Real Sociedad to their 10th away defeat following the match against Real Madrid.
Real Zaragoza boss Manolo Jimenez has acknowledged that it would be dangerous for his side to lose the ball in their own half against Atletico.
Sevilla midfielder Piotr Trochowski has urged his side to have the right attitude from the start, if the are to continue climbing the chart.
Sporting Gijon coach Javier Clemente is determined to go on the offensive against Athletic Bilbao - a team he has described as 'a Ferrari'.
Villarreal coach Miguel Angel Lotina is hoping to improve on their performance away from home and to lay the foundation for their next win.